Human lead metabolism: Chronic exposure, bone lead, and physiological models
نویسندگان
چکیده
منابع مشابه
Exposure to lead affects male biothiols metabolism.
The most important biothiols include glutathione, homocysteine (HCY), cysteine and proteins. The aim of the presented study was to evaluate the influence of lead on the biothiol turnover--the concentration of HCY and protein sulfhydryl groups (P-SH) in the serum and reduced glutathione (G-SH) in erythrocytes--in individuals (employees of metal works) exposed to lead and to evaluate its probable...
متن کاملBlood lead, ethnic origin, and lead exposure.
A survey of blood lead concentrations is reported in a group of 199 young Walsall children (3-6 years of age). The geometric mean blood lead concentration was 0.47 mumol/l (range 0.2-1.6 mumol/l). There were no significant differences in blood lead concentrations between groups of children with different ages, sex, ethnic origin, or environment.
متن کاملBone lead, hypertension, and lead nephropathy.
There is considerable clinical evidence that excessive lead absorption causes renal failure with hypertension and predisposes individuals to hypertension even in the absence of detectable renal failure. Recent analyses of transiliac bone biopsies indicate that unsuspected elevated bone leads may reflect the cause (or contributing cause) of end-stage renal disease in 5% of the European dialysis ...
متن کاملAssessment of exposure to lead through air and biological monitoring in a lead and zinc mine
Background and aim: Lead is ubiquitous and one of the earliest metals discovered by the human. This metal is widely used in different industries due to its important physico-chemical properties like softness, high malleability, ductility, low melting point and resistance to corrosion. Lead absorbed in body with several routs and when transfer in blood is primarily in red blood cells. Human exp...
متن کاملIron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
BACKGROUND Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance the oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (HFE), transferrin (TF) C2, and heme oxygenase-1 (HMOX-1)] increase ...
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ژورنال
عنوان ژورنال: Medical Physics
سال: 1999
ISSN: 0094-2405
DOI: 10.1118/1.598712